Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 000, Number 000, August 2026, pages 000-000

Systemic Sarcoidosis With Neurosarcoidosis and Obstructive Hydrocephalus: A Radiologic–Pathologic Case Report

Figures

↓  Figure 1. Axial and coronal HRCT images (lung window) demonstrating heterogeneous perihilar consolidation with airless conglomerates (yellow arrows), preserved bronchial patency, and linear pleural adhesions. HRCT: high-resolution computed tomography.
Figure 1.
↓  Figure 2. Axial HRCT image (lung window) demonstrating diffuse interstitial reticular changes with interlobular septal thickening, nodular thickening of bronchovascular bundles, and ill-defined ground-glass opacities with preserved bronchial patency. HRCT: high-resolution computed tomography.
Figure 2.
↓  Figure 3. Axial and coronal HRCT images (lung window) demonstrating multiple polymorphic nodules (yellow box) distributed along the bronchovascular bundles and interlobar pleura, without evidence of coalescence. HRCT: high-resolution computed tomography.
Figure 3.
↓  Figure 4. Coronal HRCT image (mediastinal window) demonstrating multiple enlarged mediastinal and hilar lymph nodes involving the upper and lower paratracheal, subaortic, pulmonary, subcarinal, and paraaortic stations. HRCT: high-resolution computed tomography.
Figure 4.
↓  Figure 5. Axial T2-weighted MRI demonstrating a large intraventricular mass (green arrows) arising from the choroid plexus in the atrium of the right lateral ventricle, measuring approximately 6–7 cm in maximal dimension and greater than 3 cm in thickness. MRI: magnetic resonance imaging.
Figure 5.
↓  Figure 6. Axial T2-weighted MRI demonstrating a heterogeneous lesion with multiple septations and mixed cystic and solid components, without diffusion restriction on DWI. DWI: diffusion-weighted imaging; MRI: magnetic resonance imaging.
Figure 6.
↓  Figure 7. Post-contrast axial T1-weighted MRI demonstrating intense, heterogeneous enhancement of the lesion (green arrows). MRI: magnetic resonance imaging.
Figure 7.
↓  Figure 8. Post-contrast axial T1-weighted MRI demonstrating extension of the lesion into the posterior and temporal horns of the right lateral ventricle, with near-complete obliteration and distortion of the ventricular lumen (green arrows). MRI: magnetic resonance imaging.
Figure 8.
↓  Figure 9. Axial T2-FLAIR MRI demonstrating marked periventricular white matter edema involving the adjacent temporal and occipital lobes (green arrows). FLAIR: fluid-attenuated inversion recovery; MRI: magnetic resonance imaging.
Figure 9.
↓  Figure 10. Axial T2-FLAIR MRI demonstrating moderate dilation of the lateral ventricles, more pronounced on the contralateral side (green arrows), consistent with obstructive hydrocephalus. FLAIR: fluid-attenuated inversion recovery; MRI: magnetic resonance imaging.
Figure 10.
↓  Figure 11. Histological section of the lung demonstrating marked interstitial fibrosis with distortion of the surrounding pulmonary architecture (arrow) and associated chronic inflammatory changes (hematoxylin and eosin stain, × 200).
Figure 11.
↓  Figure 12. Histological section obtained from a grossly abnormal central nervous system lesion, demonstrating epithelioid granulomatous inflammation (arrow) with a peripheral lymphocytic infiltrate (arrowhead) (hematoxylin and eosin stain, × 200).
Figure 12.
↓  Figure 13. Histological section obtained from the central nervous system lesion demonstrating non-necrotizing granulomatous inflammation (arrow) with a peripheral lymphocytic infiltrate (arrowhead) (hematoxylin and eosin stain, ×200).
Figure 13.
↓  Figure 14. Histological section of a central nervous system vessel demonstrating concentric fibrotic thickening of the vessel wall (arrow) and marked luminal narrowing (arrowhead) (hematoxylin and eosin stain, ×200).
Figure 14.