Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 17, Number 2, February 2026, pages 41-47

Giant Left Atrial Pleomorphic Sarcoma With Echocardiographic Characteristics Mimicking a Myxoma

Figures

↓  Figure 1. Mid-esophageal four-chamber view. A mass with lateral wall stalk prolapses through mitral valve during diastole. The arrow denotes the large cardiac tumor.
Figure 1.
↓  Figure 2. Mid-esophageal four-chamber view. A mass occupies the majority of the left atrium during systole. The arrow denotes the large cardiac tumor.
Figure 2.
↓  Figure 3. Mid-esophageal aortic long-axis view showing a mass obstructing the left ventricular outflow tract (LVOT) during early systole. The arrow indicates LVOT obstruction.
Figure 3.
↓  Figure 4. Mid-esophageal two-chamber view with color flow Doppler demonstrating turbulent flow around the mass through the mitral valve during diastole. The arrow indicates turbulent flow through the mitral valve.
Figure 4.
↓  Figure 5. Mid-esophageal aortic long-axis view with color flow Doppler demonstrating turbulent flow through left ventricular outflow tract (LVOT) during early systole. The arrow indicates turbulent flow through the LVOT.
Figure 5.
↓  Figure 6. Photograph of the mass following resection.
Figure 6.
↓  Figure 7. Photograph of the mass following resection during surgery.
Figure 7.
↓  Figure 8. Microscopic pathology images demonstrating cardiac undifferentiated pleomorphic sarcoma (UPS), grade 3. The histology displays variable cellularity, with areas of marked pleomorphism, as well as foci of myxoid change and focal necrosis. Mitoses are easily identified in some areas and are scarce in others. These features support the interpretation of an UPS.
Figure 8.