Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 16, Number 9, September 2025, pages 381-386

A Forty-Three-Year-Old Male With Penile and Cavernous Metastases From Rectal Cancer

Figures

Figure 1.
Figure 1. Penile ultrasound showing solid nodules in both corpora cavernosa (arrows), highly suggestive of metastatic involvement.
Figure 2.
Figure 2. Computed tomography (CT) scan showing diffuse involvement of the corpora cavernosa and pelvic floor musculature, predominantly on the right side (arrows).
Figure 3.
Figure 3. Magnetic resonance imaging (MRI) showing necrotic rectal lesion and well-defined metastatic masses in the corpora cavernosa (arrows).

Table

Table 1. Summary of Selected Reported Cases of Penile Metastasis From Colorectal Cancer
 
No.Author, yearAgePrimary siteSynchronous/metachronousOther metastatic sitesTreatment for penile metastasisSurvival from penile Dx (months)Key findings/notes
FOLFOX: folinic acid, fluorouracil, oxaliplatin; FOLFIRI: folinic acid, fluorouracil, irinotecan; CAPEOX: capecitabine, oxaliplatin; RT: radiotherapy; Sx: surgery; NA: not available; Dx: diagnosis; FOLFOXIRI: folinic acid, 5-fluorouracil, oxaliplatin and irinotecan.
1Nasrallah et al, 2024 [2]60RectumSynchronousLiver, lung, bonePalliative chemotherapy (FOLFIRI)4Presented with priapism and scrotal swelling.
2Wang et al, 2023 [3]58RectumMetachronousNone (isolated)Sx (partial penectomy) + CAPEOX + RT + immunotherapy12 (alive)Aggressive multimodal approach. No evidence of disease at 12-month follow-up.
3Lee et al, 2020 [4]67RectumMetachronousLungChemotherapy (FOLFIRI)6Penile metastasis appeared after complete response of primary.
4Efared et al, 2017 [6]68RectumSynchronousLiver, lungPalliative care2Diagnosis confirmed by penile biopsy.
5Gomez-de la Fuente et al, 2017 [11]75RectumMetachronousLiverSupportive care3Metastasis diagnosed 4 years after abdominoperineal resection.
6Zang et al, 2021 [10]78RectumMetachronousNone (isolated)Sx (total penectomy)8 (alive)Isolated penile metastasis 5 years after primary surgery.
7Kaminskas et al, 2022 [1]71ColonSynchronousLiver, peritoneumChemotherapy (FOLFOX)5Case review and report of a new case.
8Hizli et al, 2006 [7]64RectumMetachronousLung, brainNA< 6Part of a larger series on penile metastases.
9Abeshouse et al, 1961 [9]55RectumSynchronousLiver, lymph nodesNANAHistorical case from a large review.
10Our case, 202543RectumSynchronousLiverFOLFOXIRI → FOLFOX + bevacizumabAbout 7Associated with UGT1A1*28 mutation and tumor lysis syndrome.