Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 16, Number 9, September 2025, pages 381-386

A Forty-Three-Year-Old Male With Penile and Cavernous Metastases From Rectal Cancer

Figures

↓  Figure 1. Penile ultrasound showing solid nodules in both corpora cavernosa (arrows), highly suggestive of metastatic involvement.
Figure 1.
↓  Figure 2. Computed tomography (CT) scan showing diffuse involvement of the corpora cavernosa and pelvic floor musculature, predominantly on the right side (arrows).
Figure 2.
↓  Figure 3. Magnetic resonance imaging (MRI) showing necrotic rectal lesion and well-defined metastatic masses in the corpora cavernosa (arrows).
Figure 3.

Table

↓  Table 1. Summary of Selected Reported Cases of Penile Metastasis From Colorectal Cancer
 
No. Author, year Age Primary site Synchronous/metachronous Other metastatic sites Treatment for penile metastasis Survival from penile Dx (months) Key findings/notes
FOLFOX: folinic acid, fluorouracil, oxaliplatin; FOLFIRI: folinic acid, fluorouracil, irinotecan; CAPEOX: capecitabine, oxaliplatin; RT: radiotherapy; Sx: surgery; NA: not available; Dx: diagnosis; FOLFOXIRI: folinic acid, 5-fluorouracil, oxaliplatin and irinotecan.
1 Nasrallah et al, 2024 [2] 60 Rectum Synchronous Liver, lung, bone Palliative chemotherapy (FOLFIRI) 4 Presented with priapism and scrotal swelling.
2 Wang et al, 2023 [3] 58 Rectum Metachronous None (isolated) Sx (partial penectomy) + CAPEOX + RT + immunotherapy 12 (alive) Aggressive multimodal approach. No evidence of disease at 12-month follow-up.
3 Lee et al, 2020 [4] 67 Rectum Metachronous Lung Chemotherapy (FOLFIRI) 6 Penile metastasis appeared after complete response of primary.
4 Efared et al, 2017 [6] 68 Rectum Synchronous Liver, lung Palliative care 2 Diagnosis confirmed by penile biopsy.
5 Gomez-de la Fuente et al, 2017 [11] 75 Rectum Metachronous Liver Supportive care 3 Metastasis diagnosed 4 years after abdominoperineal resection.
6 Zang et al, 2021 [10] 78 Rectum Metachronous None (isolated) Sx (total penectomy) 8 (alive) Isolated penile metastasis 5 years after primary surgery.
7 Kaminskas et al, 2022 [1] 71 Colon Synchronous Liver, peritoneum Chemotherapy (FOLFOX) 5 Case review and report of a new case.
8 Hizli et al, 2006 [7] 64 Rectum Metachronous Lung, brain NA < 6 Part of a larger series on penile metastases.
9 Abeshouse et al, 1961 [9] 55 Rectum Synchronous Liver, lymph nodes NA NA Historical case from a large review.
10 Our case, 2025 43 Rectum Synchronous Liver FOLFOXIRI → FOLFOX + bevacizumab About 7 Associated with UGT1A1*28 mutation and tumor lysis syndrome.