Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 16, Number 8, August 2025, pages 287-292

An Unusual Entity in Urology: Urinary Bladder Paraganglioma

Figures

Figure 1.
Figure 1. Contrast-enhanced abdominopelvic CT of the bladder. The red arrow points at a 17-mm solid vesical nodule adjacent to the right posterolateral wall suspicious for malignancy. This was the incidental finding of the tumor. CT: computed tomography.
Figure 2.
Figure 2. Bladder MRI requested to study the lesion found in the CT scan and ultrasound. The red arrow points to a solid tumor of nodular morphology of 15-mm depending on the right posterolateral margin of the bladder. It shows well-defined contours with no signs of intraluminal extension or regional fat involvement. MRI: magnetic resonance imaging; CT: computed tomography.
Figure 3.
Figure 3. Morphologic features. (a) Neoplastic proliferation with multinodular architecture (red arrow) in the muscularis propria of the bladder (× 2). (b) Pseudorosette formation (black arrow) (× 40). (c) Irregular nests architecture (× 10).
Figure 4.
Figure 4. Morphologic features and immunohistochemistry techniques. (a) Neoplastic cells with granular eosinophilic cytoplasm, round to oval nuclei (× 20). (b) Synaptophysin (diffuse cytoplasmic staining) (× 20). (c) Chromogranin A (diffuse cytoplasmic staining) (× 20). (d) S100 highlights sustentacular cells (× 20). (e) SDHB immunoreactivity retained (× 20). (f) CKAE1/AE3 negative (× 20). SDHB: succinate dehydrogenase B; CKAE1/AE3: cytokeratin AE1/AE3.