A Rare Co-Occurrence of Gastric Heterotopia and Autonomic Nervous System Dysfunction: An Attempt to Explain If There Is a Need to Explore Possible Syndromic Link

Authors

  • Lana Alhalabi
  • Omar Alhalabi
  • Asad Khan
  • Jafer Ali
  • Prakash Gupta
  • Mohamed H. Ahmed

DOI:

https://doi.org/10.14740/jmc5185

Keywords:

Gastric heterotopia, Autonomic nervous system dysfunction, Familial dysautonomia, Congenital central hypoventilation syndrome, Hirschsprung disease

Abstract

Gastric heterotopia (GHT) is the presence of gastric mucosa outside the stomach, including in the rectum. A 59-year-old man presented with rectal bleeding and altered bowel habits, along with long-standing low blood pressure and erectile dysfunction. Investigations confirmed rectal GHT, initially managed conservatively, followed by mucosectomy, which improved his gastrointestinal symptoms. However, persistent dizziness, blurred vision, and urinary symptoms prompted neurological evaluation, revealing autonomic nervous system (ANS) dysfunction. This case represents the first reported co-occurrence of GHT and ANS dysfunction. Although both conditions are rare and typically unrelated, their co-presentation suggests a possible link. We hypothesize that chronic inflammation or neurochemical signaling from ectopic gastric mucosa may contribute to autonomic disruption. Further research is needed to explore shared pathophysiological mechanisms.

Author Biography

  • Mohamed H. Ahmed, Milton Keynes University Hospital NHS Foundation Trust

    Department of Medicine and HIV metabolic clinic, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK

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Published

2025-10-10

Issue

Section

Case Report

How to Cite

1.
Alhalabi L, Alhalabi O, Khan A, Ali J, Gupta P, Ahmed MH. A Rare Co-Occurrence of Gastric Heterotopia and Autonomic Nervous System Dysfunction: An Attempt to Explain If There Is a Need to Explore Possible Syndromic Link. J Med Cases. Published online October 10, 2025. doi:10.14740/jmc5185