Mirtazapine-Induced Premature Ventricular and Atrial Contractions

Authors

  • Sabrina Nguyen
  • Denzil Robinson
  • Alexander T. Phan
  • Haroon Azhand
  • Dan Vo

DOI:

https://doi.org/10.14740/jmc4265

Keywords:

Mirtazapine, Premature ventricular contraction, Premature atrial contraction, Medication adverse effects, Tachycardia

Abstract

Mirtazapine, an alpha-2 adrenergic receptor, 5-hydroxytryptamine (5-HT)2, and 5-HT3 antagonist, is commonly used in patients for depression and anorexia. Its mechanism disinhibits serotonin and norepinephrine. Though typically a well-tolerated medication, a rare adverse effect is arrhythmia, including ventricular bigeminy. To date, no case report has cited normal dosing of mirtazapine as a cause of premature ventricular or premature atrial contractions. Only cases of mirtazapine overdose have been associated with arrhythmias, including QT prolongation and bradycardia. We report on a unique case of a 64-year-old female who developed sinus tachycardia with premature ventricular and atrial contractions after starting mirtazapine.

jmc4265

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Published

2024-11-12

Issue

Section

Case Report

How to Cite

1.
Nguyen S, Robinson D, Phan AT, Azhand H, Vo D. Mirtazapine-Induced Premature Ventricular and Atrial Contractions. J Med Cases. 2024;12(12):376-381. doi:10.14740/jmc4265